For an oocyte to become Prepared for fertilization and growth into an embryo, the proper list of genes has to be turned on. Namekawa suspected this pre-programming with the oocyte genome comes about in many levels — the primary a person starting throughout the time a feminine is born. He thought that chromatin remodeling proteins did A lot of this perform, by shifting spools about.
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Munakata and Namekawa will Look at mice with regular and mutated variations of your chromatin remodeler. Because the mice develop and mature, they can observe whether or not the presence or absence of this protein triggers variations in the arrangement of DNA spools from the animals’ oocytes. And they'll check regardless of whether this, in turn, alters the pattern of gene expression with time.
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